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Many standard applications now have flags to run multithreaded. Threaded applications can use multiple cores on a node, but each multithreaded process/job requires access to the same physical memory on the node and it is therefore limited to run on a single node (i.e. shared memory). The most common type of multithread application uses the OpenMP application programming interface http://www.openmp.org
To submit a job that uses multiple cores, you must specify the number of job cores you want to use with the sbatch flag -c Ncores. The maximum number of cores that can be requested with this approach is 20
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